Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TGFβ determines epithelial tissue spacing by regulating mesenchymal condensation.

Cell reports·2026
Same author

The mechanical microenvironment and lung stem cell fate.

Frontiers in cell and developmental biology·2026
Same author

Patterns of mitochondrial ATP predict tissue folding.

Science advances·2026
Same author

TGFβ determines epithelial tissue spacing by regulating mesenchymal condensation.

bioRxiv : the preprint server for biology·2026
Same author

Fat promotes growth and invasion in a 3D microfluidic tumor model of triple-negative breast cancer.

APL bioengineering·2026
Same author

Effects of Topography and Extracellular Matrix Composition on Focal Adhesion Patterning in Human Corneal Fibroblasts.

International journal of molecular sciences·2025

Related Experiment Video

Updated: Apr 30, 2026

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering
08:00

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Published on: November 25, 2011

22.4K

Toward the directed self-assembly of engineered tissues.

Victor D Varner1, Celeste M Nelson

  • 1Departments of 1Chemical & Biological Engineering and.

Annual Review of Chemical and Biomolecular Engineering
|May 7, 2014
PubMed
Summary

Tissue engineering uses scaffolds to create lab-grown tissues, but functional gaps remain. Physical cues guide tissue growth and remodeling, improving engineered tissue self-assembly.

Keywords:
biomechanicscomputational modelingdevelopmentembryogrowth and remodelingtissue engineering

More Related Videos

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds
08:16

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Published on: April 2, 2018

12.7K
Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

14.2K

Related Experiment Videos

Last Updated: Apr 30, 2026

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering
08:00

Directed Cellular Self-Assembly to Fabricate Cell-Derived Tissue Rings for Biomechanical Analysis and Tissue Engineering

Published on: November 25, 2011

22.4K
Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds
08:16

Fabrication of Custom Agarose Wells for Cell Seeding and Tissue Ring Self-assembly Using 3D-Printed Molds

Published on: April 2, 2018

12.7K
Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets
09:24

Tissue Engineering: Construction of a Multicellular 3D Scaffold for the Delivery of Layered Cell Sheets

Published on: October 3, 2014

14.2K

Area of Science:

  • Biomedical Engineering
  • Tissue Engineering
  • Soft Tissue Biomechanics
  • Developmental Biology

Background:

  • Scaffold-based approaches are advancing laboratory-created replacement tissues.
  • Engineered tissues often lack the functional properties of native tissues.
  • Limited quantitative understanding of growth and remodeling hinders progress.

Purpose of the Study:

  • To explore how physical cues influence the adaptive growth and remodeling of engineered tissues.
  • To quantitatively characterize the mechanics of growth and remodeling in tissue constructs.
  • To inform the design of novel tissue engineering strategies.

Main Methods:

  • Review of experimental and computational studies.
  • Analysis of physical cues directing tissue adaptive responses.
  • Integration of concepts from soft tissue biomechanics and developmental biology.

Main Results:

  • Physical cues quantitatively direct the mechanics of growth and remodeling in engineered tissues.
  • Understanding these mechanisms is crucial for matching native tissue function.
  • Advances enable better control over engineered tissue self-assembly.

Conclusions:

  • Quantitative understanding of physical cues' role in growth and remodeling is key.
  • This knowledge can improve the functional outcomes of engineered tissues.
  • Future tissue engineering designs can leverage these insights for self-assembly.