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Related Concept Videos

Pigmentation01:19

Pigmentation

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The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
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The orderly progression of the cell cycle depends on the activation of Cdk protein by binding to its cyclin partner. However, the cell cycle must be restricted when undergoing abnormal changes. Most cancers correlate to the deregulated cell cycle, and since Cdks are a central component of the cell cycle, Cdk inhibitors are extensively studied to develop anticancer agents. For instance, cyclin D associates with several Cdks, such as Cdk 4/6, to form an active complex. The cyclin D-Cdk4/6 complex...
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Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model
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The inhibitory effect of a Platycodon root extract on ultraviolet B-induced pigmentation due to a decrease in Kit

Shinya Kasamatsu1, Akira Hachiya, Yoshie Shimotoyodome

  • 1Biological Science Laboratories, Kao Corporation, Haga, Tochigi, 321-3497, Japan.

Journal of Natural Medicines
|May 7, 2014
PubMed
Summary
This summary is machine-generated.

A Platycodon root extract effectively inhibits skin pigmentation by reducing stem cell factor (SCF)/Kit signaling. This botanical extract shows promise as a natural skin-lightening agent for treating hyperpigmentation.

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Area of Science:

  • Dermatology
  • Molecular Biology
  • Cosmetic Science

Background:

  • Stem cell factor (SCF) signaling via its receptor Kit is crucial for regulating skin pigmentation (melanogenesis).
  • UVB radiation increases SCF expression in keratinocytes, activating melanocytes and leading to hyperpigmentation.

Purpose of the Study:

  • To identify botanical extracts with skin-lightening properties by screening for inhibitors of Kit expression in melanocytes.
  • To evaluate the efficacy of Platycodon root extract in reducing UVB-induced pigmentation.

Main Methods:

  • Screening of botanical extracts for their ability to inhibit Kit expression.
  • In vitro testing on three-dimensional human skin substitutes.
  • In vivo testing on human skin following UVB irradiation.

Main Results:

  • Platycodon root extract demonstrated significant inhibitory activity on Kit expression in melanocytes.
  • Application of the extract reduced pigmentation in UVB-irradiated human skin substitutes and human skin.
  • Suppression of SCF/Kit signaling was confirmed as a key mechanism for inhibiting melanin synthesis.

Conclusions:

  • Platycodon root extract is a potent inhibitor of SCF/Kit signaling, effectively reducing skin pigmentation.
  • This extract represents a promising natural ingredient for developing novel skin-lightening products.
  • The findings support the use of Platycodon root extract for managing pigmentation-related skin conditions.