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Radiation-induced osteosarcoma of the hand: case report
Mark E Puhaindran1, Kendall Hamilton1, Stacy Schlumbohm1
1Department of Hand and Reconstructive Microsurgery, National University Hospital, Singapore; The Orthopaedic Surgery Residency Program, Grand Rapids Medical Education Partners, Grand Rapids, MI; Department of Pediatric Hematology/Oncology, Helen DeVos Children's Hospital, Grand Rapids, MI; Spectrum Health Medical Group, Grand Rapids, MI; Van Andel Research Institute, Grand Rapids, MI; Department of Surgery, Michigan State University College of Human Medicine, Grand Rapids, MI.
Radiation-associated sarcomas are rare, developing after radiotherapy. This case shows a rapidly progressing radiation-associated osteosarcoma in the hand, emphasizing the need for awareness among patients and physicians.
Area of Science:
- Oncology
- Radiotherapy
- Sarcoma Research
Background:
- Radiation-associated sarcomas (RAS) are rare malignancies, accounting for less than 5% of all sarcomas.
- These tumors can develop in previously irradiated bone or soft tissue.
- Synovial sarcoma is a type of soft tissue sarcoma.
Observation:
- A case of radiation-associated osteosarcoma is presented.
- The osteosarcoma developed in the hand of a patient with a history of treated synovial sarcoma.
- The patient had previously undergone radiotherapy to the hand.
Findings:
- The radiation-associated osteosarcoma in the hand exhibited rapid progression.
- Aggressive, multimodality treatment was administered.
- Despite treatment, the disease advanced quickly.
Implications:
- This case underscores the potential complication of radiotherapy, specifically the development of radiation-associated osteosarcoma.
- Increased awareness is crucial for both patients and treating physicians regarding this risk after hand radiotherapy.
- Early recognition and management strategies for radiation-associated sarcomas may be warranted.
