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Psoriasis beyond the skin surface: a pilot study on the ocular involvement.
A Campanati1, P Neri, K Giuliodori
1Dermatology Unit, University of Marche, Azienda Ospedaliera Universitaria-Ospedali Riuniti di, Ancona Via Conca 71, 60126, Ancona, Torrette, Italy.
International Ophthalmology
|May 7, 2014
Summary
Psoriasis patients frequently experience ocular involvement, particularly dry eye symptoms. A 12-week immunosuppressive therapy improved ocular surface disease and psoriasis severity, highlighting the need for regular eye exams in psoriatic individuals.
Area of Science:
- Ophthalmology
- Dermatology
- Immunology
Background:
- Ocular involvement in psoriasis is underrecognized, affecting approximately 10% of patients.
- Ophthalmologic manifestations are more prevalent in arthropathic or pustular psoriasis and in males, often coinciding with disease exacerbations.
Purpose of the Study:
- To determine the prevalence and characteristics of ocular involvement in psoriasis.
- To compare ocular findings between psoriatic patients and healthy controls.
- To evaluate the impact of a 12-week systemic immunosuppressive therapy on ocular and dermatological parameters.
Main Methods:
- Thirty-two psoriatic patients and 32 healthy controls underwent dermatological (PASI, PGA, DLQI) and ophthalmological evaluations (Schirmer, Jones, BUT, DR-1 camera).
- Ocular surface disease index and C-reactive protein (CRP) levels were assessed.
- Patients received 12-week systemic immunosuppressive therapy.
Main Results:
- Psoriatic patients exhibited significantly lower Schirmer, Jones, and BUT test values and more frequent conjunctival hyperemia compared to controls.
- Ocular involvement was more pronounced in sebo-psoriasis, with significant correlations between PASI and Schirmer, Jones, and BUT tests.
- After 12 weeks of therapy, significant improvements were observed in PASI, PGA, DLQI, CRP, and BUT values.
Conclusions:
- Psoriasis is associated with a high rate of ocular involvement, particularly dry eye disease.
- Sebo-psoriasis shows a stronger link with ocular surface parameters.
- Systemic immunosuppressive therapy can ameliorate both psoriasis severity and ocular surface disease, underscoring the importance of routine ophthalmological screening for early detection and management.
