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Chemotherapy engages multiple pathways leading to IL-1β production by myeloid leukocytes

Christina Antonopoulos1, George R Dubyak2

  • 1Department of Pathology; Case Western Reserve University School of Medicine; Cleveland, OH USA.

Oncoimmunology
|May 7, 2014
PubMed

Interleukin-1β (IL-1β) can limit tumor growth by promoting T cell-mediated antitumor immune responses. Several chemotherapeutic agents can stimulate the production of IL-1β by tumor-infiltrating leukocytes via the NLRP3 inflammasome. We have recently demonstrated that some chemotherapeutics can also trigger the secretion of IL-1β by driving the assembly of the caspase-8- and FADD-containing platform known as the ripoptosome.

Keywords:
IL-1βcaspase-1caspase-8chemotherapyinflammasomeripoptosome

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