Related Experiment Video
Updated: Apr 30, 2026

Evaluating Cell Death Using Cell-Free Supernatant of Probiotics in Three-Dimensional Spheroid Cultures of Colorectal Cancer Cells
Published on: June 13, 2020
Why should we need the gut microbiota to respond to cancer therapies?
Sophie Viaud1, Romain Daillère1, Takahiro Yamazaki2
1Institut National de la Santé et de la Recherche Médicale; U1015; Gustave Roussy; Villejuif, France ; Université Paris-Sud; Kremlin Bicêtre France.
Abstract:
Cyclophosphamide, one of the most efficient tumoricidal, antiangiogenic, and immunostimulatory drugs employed to date mediates part of its effects through intestinal bacteria, against which the host becomes immunized during treatment. Our recent work suggests that anti-commensal effector pTH17 and memory TH1 CD4+ T-cell responses are indispensable for optimal anticancer effects as mediated by cyclophosphamide.
More Related Videos
Related Concept Videos
Tumor Immunotherapy
The Tumor Microenvironment
The Tumor Microenvironment
Functions of the Gut Microbiota
Cancer Therapies
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
Microbiota of the Large Intestine

