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Published on: October 20, 2016
Application of iPS cell-derived macrophages to cancer therapy
Satoru Senju1, Chihiro Koba1, Miwa Haruta1
1Department of Immunogenetics; Graduate School of Medical Sciences; Kumamoto University; Kumamoto, Japan ; CREST; Japan Science and Technology Agency; Kawaguchi, Japan.
Abstract:
We established a method to produce a large quantity of myeloid cells from human inducible pluripotent stem cells (iPSCs). When injected intraperitoneally into mice carrying established peritoneal tumors, iPSC-derived myeloid cells (iPS-MCs) efficiently accumulated within neoplastic lesions. The intraperitoneal injection of iPS-MCs expressing interferon β significantly inhibited the growth of human gastric and pancreatic cancers implanted in the peritoneal cavity of immunocompromised mice.

