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Is tumor (R)ejection by the immune system the "5th R" of radiobiology?
Encouse B Golden1, Silvia C Formenti1
1Department of Radiation Oncology; New York University School of Medicine; New York, NY USA.
Oncoimmunology
|May 7, 2014
Abstract:
Traditional factors of DNA damage and tumor cell kill, described by the "4 R's" of radiobiology (Reassortment, Reoxygenation, Repair, and Repopulation) fall short in explaining the role of immunity in hosts treated with radiotherapy. We propose a "5th R," (immune-mediated) Rejection, which recognizes the contribution of the immune system to the antineoplastic effects of radiotherapy.
Keywords:
ATPCTLA4CXCL16CXCR6HMGB1NKG2DRAE-1abscopal effectcalreticulinimmunogenic cell deathionizing irradiationipilimumabradiobiologyMore Related Videos
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