Related Experiment Video
Updated: Apr 30, 2026
11:15
Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
26.1K
[Genomics medicine and oncology]
Olivier Michielin1, George Coukos1
1Département d'oncologie, CHUV Lausanne.
Praxis
|May 8, 2014
Summary
High throughput next generation sequencing is transforming cancer care by identifying genetic mutations. This allows for personalized treatments and improved patient outcomes in oncology.
Area of Science:
- Genomics
- Oncology
- Personalized Medicine
Background:
- Genomic advancements, particularly next-generation sequencing (NGS), are revolutionizing oncology.
- NGS enables the identification of germline mutations linked to cancer predisposition.
- It also characterizes acquired somatic mutations in tumor cells for targeted therapies.
Purpose of the Study:
- To highlight the transformative impact of NGS in oncology.
- To demonstrate how NGS facilitates personalized cancer care through genetic analysis.
- To underscore the correlation between genomic mutations and clinical data.
Main Methods:
- Utilizing high throughput next-generation sequencing techniques.
- Analyzing the integrality of genome mutations.
- Correlating genomic data with clinical information.
Main Results:
- Identification of germline mutations for personalized patient care.
- Characterization of somatic mutations for targeted driver oncogene treatments.
- Global genomic analysis enabling a comprehensive approach to cancer.
Conclusions:
- Next-generation sequencing significantly advances oncology by enabling personalized care.
- The comprehensive analysis of mutations improves treatment strategies and patient outcomes.
- Genomic insights derived from NGS are crucial for the future of cancer treatment.
Keywords:
Mutations germinalescancer héréditairescancer sporadiquesgerminal mutationsgerminale Mutationenhereditary cancermutations somatiquesmédecine personnaliséepersonalised medicinepersonalisierte Medizinsomatic mutationssomatische Mutationensporadic cancersporadischer Tumorvererbbarer TumorMore Related Videos
13:24Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
Published on: April 11, 2016
14.0K
11:02Detecting Somatic Genetic Alterations in Tumor Specimens by Exon Capture and Massively Parallel Sequencing
Published on: October 18, 2013
19.0K
Related Concept Videos
02:02Genomics
35.5K
Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
35.5K
02:50Combination Therapies and Personalized Medicine
4.9K
Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
4.9K
02:50Combination Therapies and Personalized Medicine
1.5K
1.5K
01:29Pharmacogenomics: Identification of New Drug Targets
121
Advances in genomics have profoundly influenced drug discovery by increasing both the speed and accuracy of pharmaceutical development. Pharmacogenomics, which examines how genetic variation influences drug response, facilitates the identification of novel therapeutic targets and enables patient stratification for personalized treatment. These strategies contribute to improved drug efficacy, minimized adverse effects, and more efficient clinical trial design.Mapping genetic differences...
121
02:18Cancer
51.7K
Cancers arise due to mutations in genes involved in the regulation of cell division, which leads to unrestricted cell proliferation. Modern science and medicine have made great strides in the understanding and treatment of cancer, including eradicating cancer in some patients. However, there is still no cure for cancer. This is largely due to the fact that cancer is a large group of many diseases.
51.7K
01:29Pharmacogenetics and Pharmacogenomics: Overview
253
Pharmacogenetics and pharmacogenomics examine how genetic factors influence an individual's response to drugs. While pharmacogenetics focuses on the impact of specific genetic variants on drug effects, pharmacogenomics takes a broader approach, studying how genetic variation across populations contributes to differences in drug responses. These fields aim to explain why individuals may experience varying levels of efficacy or adverse reactions to the same medication.Variability in drug...
253