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[Blockage of a mitochondrial cationic channel by a mitochondrial addressing peptide]
J P Henry1, J F Chich, D Goldschmidt
1Unité de Neurobiologie Physico-Chimique, C.N.R.S., Institut de Biologie Physico-Chimique, Paris.
Abstract:
A 13-residue peptide, including the sequence of the amino terminal end of cytochrome c oxidase subunit IV precursor, blocks a cationic channel from mitochondrial membranes. The effect is reversible and voltage-dependent. The blocking properties suggest that the peptide plugs the pore. Furthermore, when the transmembrane potential favours transfer, the peptide appears to be able to cross the channel.