Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioplastics01:27

Bioplastics

70
Bioplastics derived from microbial processes present a sustainable alternative to conventional petroleum-based plastics. Among these, polyhydroxyalkanoates (PHAs), particularly polyhydroxybutyrates (PHBs), have emerged as prominent candidates due to their biodegradability and biocompatibility. These polymers are synthesized by a variety of bacteria, such as Cupriavidus necator and Pseudomonas putida, which naturally accumulate PHAs as intracellular carbon and energy reserves, especially under...
70
Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

1.7K
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the...
1.7K
Microbial Bioremediation of Plastics01:28

Microbial Bioremediation of Plastics

131
Polyethylene terephthalate (PET) is a synthetic polymer widely utilized in the packaging industry, particularly for bottles and containers. Due to its chemical stability and durability, PET accumulates in the environment, contributing significantly to plastic pollution. It comprises repeating units of terephthalic acid and ethylene glycol, resulting in a semi-crystalline structure that is resistant to natural degradation processes.A notable breakthrough in plastic biodegradation came with the...
131

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Functional Hydrogels for Selective Phosphate Removal from Water and Release on Demand.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

DendriPep Nanocoats: Substrate-Agnostic, Self-Assembling Constructs with Shear-Controlled Thickness and Permeability.

Langmuir : the ACS journal of surfaces and colloids·2025
Same author

InP-Based Quantum Dots as Photosensitizers in Photodynamic Antimicrobial Materials.

ACS applied bio materials·2025
Same author

Liquid Metal Nanoparticles as Initiators for Radical Polymerization of Vinyl Monomers.

ACS macro letters·2022
Same author

Degradable Anti-Biofouling Polyester Coatings with Controllable Lifetimes.

Langmuir : the ACS journal of surfaces and colloids·2022
Same author

Dynamic Surfaces-Degradable Polyester Networks that Resist Protein Adsorption.

Langmuir : the ACS journal of surfaces and colloids·2021
Same journal

Corrigendum to "Senescent endothelial cells' response to the degradation of bioresorbable scaffold induces intimal dysfunction accelerating in-stent restenosis" [Acta Biomaterialia 166 (2023) 266-277].

Acta biomaterialia·2026
Same journal

Colorectum and embedded networks of nerve fibers present auxetic responses during uniaxial circumferential extension.

Acta biomaterialia·2026
Same journal

Music-Inspired Acoustic-Piezoelectric Stimulation Accelerates Extracellular Vesicle Production and Programs Therapeutic Function.

Acta biomaterialia·2026
Same journal

Mutant superoxide dismutase 1-catalyzed hydrogen therapy for amyotrophic lateral sclerosis achieved by intercepting oxidative stress-neuroinflammation crosstalk.

Acta biomaterialia·2026
Same journal

Injectable pH-responsive gelatin methacryloyl hydrogel for cuproptosis-synergized sunitinib therapy and immune reprogramming in clear cell renal cell carcinoma.

Acta biomaterialia·2026
Same journal

Corrigendum to "Injectable hydrogel-assisted local lipopolysaccharide delivery improves immune checkpoint blockade therapy" [Acta Biomaterialia 2025, 194, 153-168].

Acta biomaterialia·2026
See all related articles

Related Experiment Video

Updated: Apr 30, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

18.8K

Resisting protein adsorption on biodegradable polyester brushes.

Xinfang Hu1, Christopher B Gorman1

  • 1Department of Chemistry, North Carolina State University, Box 8204, Raleigh, NC 27695, USA.

Acta Biomaterialia
|May 8, 2014
PubMed
Summary
This summary is machine-generated.

Researchers studied protein resistance and degradation of polyester and oligo(ethylene glycol) (OEG) copolymer brushes. Optimizing OEG amount and placement created protein-resistant, yet degradable, poly(glycolic acid) brushes.

Keywords:
AdsorptionCopolymerDegradationElectrochemistryPolyester

More Related Videos

Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices
10:57

Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices

Published on: April 22, 2022

8.5K
Preparation of Polypentafluorophenyl acrylate Functionalized SiO2 Beads for Protein Purification
08:51

Preparation of Polypentafluorophenyl acrylate Functionalized SiO2 Beads for Protein Purification

Published on: November 19, 2018

9.2K

Related Experiment Videos

Last Updated: Apr 30, 2026

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications
09:22

Fabricating Superhydrophobic Polymeric Materials for Biomedical Applications

Published on: August 28, 2015

18.8K
Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices
10:57

Generation of Greater Bacterial Biofilm Biomass using PCR-Plate Deep Well Microplate Devices

Published on: April 22, 2022

8.5K
Preparation of Polypentafluorophenyl acrylate Functionalized SiO2 Beads for Protein Purification
08:51

Preparation of Polypentafluorophenyl acrylate Functionalized SiO2 Beads for Protein Purification

Published on: November 19, 2018

9.2K

Area of Science:

  • Polymer Science
  • Biomaterials Engineering
  • Surface Chemistry

Background:

  • Polymeric biomaterials like poly(lactic acid), poly(glycolic acid) (PGA), and poly(ε-caprolactone) (PCL) are crucial in biomedical applications.
  • Controlling protein adsorption and degradation is essential for effective biomaterial performance.
  • Copolymerization with oligo(ethylene glycol) (OEG) is a strategy to impart protein resistance.

Purpose of the Study:

  • To investigate the influence of brush structure and composition on protein adsorption and degradation.
  • To determine optimal configurations for creating surfaces that are both protein-resistant and degradable.
  • To understand the mechanism by which OEG affects polyester degradation.

Main Methods:

  • Synthesis and characterization of poly(lactic acid), PGA, and PCL brushes.
  • Creation of copolymer brushes with varying OEG content and architecture.
  • Evaluation of protein adsorption using surface-sensitive techniques.
  • Assessment of degradation rates under physiological conditions.

Main Results:

  • Both brush architecture and the relative amount of OEG significantly impact protein resistance.
  • Protein-resistant surfaces were achieved by using OEG as the top layer or increasing OEG concentration.
  • Degradation of polyester brushes was hindered when OEG end groups blocked polyester hydroxyl termini.
  • Poly(glycolic acid) (PGA) copolymer brushes with a methoxy/hydroxyl OEG mixture substrate showed excellent protein resistance and degradability.

Conclusions:

  • The strategic placement and quantity of OEG in copolymer brushes are key to achieving desired surface properties.
  • OEG can effectively inhibit polyester degradation by blocking reactive end groups.
  • Poly(glycolic acid) copolymer brushes with specific OEG configurations offer a promising combination of protein resistance and controlled biodegradability for biomedical applications.