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Takayasu's arteritis in Arabs.

Khader N Mustafa1

  • 1Division of Rheumatology, Department of Internal Medicine, Jordan University Hospital, The University of Jordan, Queen Rania St, PO Box 13046, Amman, 11942, Jordan, kmustafa@ju.edu.jo.

Clinical Rheumatology
|May 8, 2014
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Summary

Takayasu

Area of Science:

  • Vascular Medicine
  • Epidemiology
  • Rheumatology

Background:

  • Takayasu's arteritis (TA) is a rare, chronic inflammatory disease affecting large arteries, primarily the aorta and its branches.
  • Understanding TA's epidemiological and clinical spectrum in diverse populations is crucial for timely diagnosis and management.
  • Arab populations represent a unique demographic for studying TA due to potential genetic and environmental factors.

Purpose of the Study:

  • To delineate the epidemiological and clinical characteristics of Takayasu's arteritis (TA) within Arab populations.
  • To compare the features of TA in Arab patients with those reported globally.
  • To identify potential factors contributing to diagnostic delays in TA.

Main Methods:

  • A systematic review of published literature on Takayasu's arteritis (TA) from Arab countries (until 2013) was performed.

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  • Data from original research articles and case reports were aggregated and analyzed.
  • Demographic, clinical, and outcome data were extracted and synthesized.

    • Main Results:

    • The review identified 197 TA patients (7:1 female to male ratio; mean age at onset 28 years) from Arab countries.
    • Common manifestations included limb claudication (64%), neurological symptoms (56%), and hypertension (34.5%). Aortic arch involvement was observed in ~80%.
    • The mean diagnostic delay was 3.5 years, and overall mortality was low, with disease stability in ~50% of patients.

    Conclusions:

    • Demographic and clinical findings of TA in Arab populations are largely consistent with global reports.
    • A significant delay in diagnosis suggests a need for increased awareness of TA among healthcare providers in the region.
    • Further research is warranted to explore regional specificities and optimize early detection strategies for Takayasu's arteritis.