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Age-related differences in urinary 11-dehydroxythromboxane B2 between infants, children, and adolescents: another

Charles D Varnell1, Stuart L Goldstein, Donald L Yee

  • 1Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.

Pediatric Blood & Cancer
|May 8, 2014
PubMed

Insights

This study establishes pediatric reference ranges for urinary 11-dehydrothromboxane B2 (11-dhTXB2). Researchers found that 11-dhTXB2 levels decrease with age in healthy children not taking aspirin.

Area of Science:

  • Biochemistry
  • Pediatric Medicine
  • Clinical Chemistry

Background:

  • Thromboxane B2 is a key metabolite in platelet aggregation and vascular homeostasis.
  • Urinary 11-dehydrothromboxane B2 (11-dhTXB2) serves as a marker for thromboxane production.
  • Establishing age-specific reference ranges for 11-dhTXB2 in pediatric populations is crucial for accurate clinical assessment.

Purpose of the Study:

  • To determine the reference ranges of urinary 11-dehydrothromboxane B2 (11-dhTXB2) in healthy children.
  • To investigate the correlation between age and urinary 11-dhTXB2 levels in a pediatric cohort.
  • To provide age-specific reference values for 11-dhTXB2 in urine.

Main Methods:

  • Analysis of urine samples from 128 healthy pediatric subjects aged 2 months to 18 years.
  • Utilized the AspirinWorks™ assay for the quantitative measurement of 11-dehydrothromboxane B2 (11-dhTXB2).
  • Expressed 11-dhTXB2 levels relative to urine creatinine (picograms/milligram urine creatinine).

Main Results:

  • A statistically significant negative correlation was observed between age and urinary 11-dehydrothromboxane B2 (11-dhTXB2) levels (P = 0.0001).
  • Older children exhibited lower concentrations of 11-dhTXB2 compared to younger children.
  • The study successfully generated a comprehensive set of age-specific reference ranges for 11-dhTXB2.

Conclusions:

  • Confirms a significant inverse relationship between chronological age and urinary 11-dehydrothromboxane B2 (11-dhTXB2) in healthy children.
  • The established age-specific reference ranges are valuable for interpreting 11-dhTXB2 levels in pediatric clinical practice.
  • These findings contribute to a better understanding of thromboxane metabolism during childhood development.

Keywords:
aspirinchildrenneonatespediatricthromboxane

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