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Updated: Apr 30, 2026
Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Statins improve survival in patients with cardioembolic stroke
Jeong-Yoon Choi1, Woo-Keun Seo2, Sung Hoon Kang1
1From the Department of Neurology, Korea University Ansan Hospital, Ansan, GyeongGi Province, Korea (J.-Y.C., J.-M.J.); Department of Neurology, Korea University Guro Hospital, Seoul, Korea (W.-K.S., S.H.K., K.O.); and Department of Neurology, Korea University Anam Hospital, Seoul, Korea (K.-H.C., S.Y.).
Background And Purpose:
The objective of this study was to investigate the potential benefits of statin therapy on mortality and stroke recurrence after cardioembolic stroke.
Methods:
In this retrospective observational study, we analyzed data from 535 patients with first-ever cardioembolic stroke. Patients were classified into nonstatin, low-potency statin, and high-potency statin groups. The primary outcomes were time to mortality and time to recurrent stroke.
Results:
The mean duration of follow-up was 22.2 months. The cumulative mortality rate was 7% at the end of the first year and 10% at the end of the third year. Statin therapy was independently associated with reduced mortality (hazard ratio, 0.237; 95% confidence interval, 0.080-0.703 for nonstatin versus low-potency statin; hazard ratio, 0.158; 95% confidence interval, 0.037-0.686 for nonstatin versus high-potency statin). Statin treatment did not affect the incidence of recurrent stroke in patients with cardioembolic stroke.
Conclusions:
Statin therapy could be associated with reduced mortality in patients with cardioembolic stroke.
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