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Skin necrosis associated with thromboprophylaxis after total knee replacement
S V Karuppiah1, A J Johnstone2
1Department of Trauma & Orthopaedics, Grampian University Hospitals NHS Trust, Aberdeen Royal Infirmary, Aberdeen AB25 2ZN, UK ; 4, Drake Close, Hethersette, Norwich NR9 3JS, UK.
Case Reports in Orthopedics
|May 8, 2014
Summary
Low molecular weight heparin (LMWH) prevents blood clots after surgery but can rarely cause skin necrosis. This case highlights a rare complication of LMWH (tinzaparin) following knee replacement surgery.
Area of Science:
- Medicine
- Pharmacology
- Surgery
Background:
- Venous thromboembolism (VTE) prophylaxis is standard after hip and knee replacements.
- Low molecular weight heparin (LMWH) is widely used for VTE prevention due to its predictable effects.
- While generally safe, LMWH can have rare complications.
Purpose of the Study:
- To report a rare case of skin necrosis.
- To investigate a complication associated with LMWH thromboprophylaxis.
Main Methods:
- A case report detailing a patient's experience.
- Review of clinical data related to LMWH use.
Main Results:
- The patient developed skin necrosis.
- The complication was secondary to the use of tinzaparin, a type of LMWH.
Conclusions:
- Skin necrosis is a rare but possible adverse event associated with LMWH.
- Clinicians should be aware of this potential complication even with routine thromboprophylaxis.
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