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Updated: Aug 12, 2026

HSV-Mediated Transgene Expression of Chimeric Constructs to Study Behavioral Function of GPCR Heteromers in Mice
Published on: July 9, 2016
Cloning by functional expression of a member of the glutamate receptor family
M Hollmann1, A O'Shea-Greenfield, S W Rogers
1Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037.
Abstract:
We have isolated a complementary DNA clone by screening a rat brain cDNA library for expression of kainate-gated ion channels in Xenopus oocytes. The cDNA encodes a single protein of relative molecular mass (Mr) 99,800 which on expression in oocytes forms a functional ion channel possessing the electrophysiological and pharmacological properties of the kainate subtype of the glutamate receptor family in the mammalian central nervous system.
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