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Asthma and other recurrent wheezing disorders in children (acute)

Augusta Okpapi1, Amanda Jane Friend, Stephen William Turner

  • 1Royal Aberdeen Children's Hospital, Aberdeen, UK.

BMJ Clinical Evidence
|May 9, 2014
PubMed

Insights

This systematic review evaluates treatments for acute childhood asthma, examining interventions like beta2 agonists and corticosteroids. Evidence quality was assessed using the GRADE system to determine effectiveness and safety in pediatric patients.

Area of Science:

  • Pediatric Pulmonology
  • Clinical Emergency Medicine
  • Evidence-Based Medicine

Background:

  • Acute childhood asthma is a frequent pediatric emergency.
  • Presentations vary widely in age and severity.

Purpose of the Study:

  • To systematically review the effects of various treatments for acute asthma in children.
  • To assess the effectiveness and safety of key interventions.

Main Methods:

  • Conducted a systematic literature review up to June 2010.
  • Searched major databases (Medline, Embase, Cochrane Library).
  • Included harms alerts from regulatory agencies (FDA, MHRA).

Main Results:

  • Included 35 systematic reviews, RCTs, and observational studies.
  • Evaluated the quality of evidence using the GRADE system.
  • Assessed interventions including beta2 agonists, corticosteroids, ipratropium bromide, magnesium sulfate, oxygen, and theophylline/aminophylline.

Conclusions:

  • Presents information on the effectiveness and safety of evaluated asthma treatments.
  • Highlights the GRADE assessment of evidence quality for pediatric asthma interventions.
Abstract

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