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Antigen-induced mixed and separated inflammation in murine upper and lower airways

Mayumi Saeki1, Tomoe Nishimura1, Akio Mori2

  • 1Allergy and Immunology Project, Tokyo Metropolitan Institute of Medical Science, Tokyo, Japan.

Allergology International : Official Journal of the Japanese Society of Allergology
|May 10, 2014
PubMed
Abstract

No abstract available in PubMed .

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Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
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