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Sinusoidal Obstruction Syndrome With Inotuzumab Ozogamicin Combined With Ponatinib for
Emi Yokoyama1, Satoshi Ota2, Yasuo Sakurai3,4
1Blood Disorders Center Aiiku Hospital Sapporo Japan.
Introduction:
Sinusoidal obstruction syndrome, also known as veno-occlusive disease (SOS/VOD), can occur after exposure to inotuzumab ozogamicin (InO), a calicheamicin-based antibody-drug conjugate.
Case Presentation:
We experienced two cases of SOS/VOD after treatment with InO combined with intermittent administration of ponatinib without hematopoietic stem cell transplantation for Philadelphia-chromosome-positive (Ph+) lymphoblastic malignancies. Both cases developed SOS/VOD after two courses of InO. Ultrasound scoring system and pathological assessment were useful for diagnosis of SOS/VOD.
Conclusion:
This is the first report warning of the potentially high risk of developing SOS/VOD with the combination of InO and ponatinib, both of which can induce endothelial cell damage.
Trial Registration:
The authors have confirmed clinical trial registration is not needed for this submission.
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