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Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

598
Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
598
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

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Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.2K
Aortic Regurgitation I: Introduction01:15

Aortic Regurgitation I: Introduction

1.6K
IntroductionAortic regurgitation is characterized by the backward flow of blood from the aorta into the left ventricle during diastole and arises from the improper closure of the aortic valve. This condition results in left ventricular volume overload and can stem from both acute and chronic etiologies, each contributing uniquely to the disease's progression and symptomatology.Acute and Chronic CausesAcute aortic regurgitation often results from events that suddenly impair the integrity of the...
1.6K
Mitral Stenosis III: Medical Management01:26

Mitral Stenosis III: Medical Management

532
Mitral stenosis, a condition marked by the narrowing of the mitral valve, necessitates an integrated approach for effective management. This approach includes preventative measures, medical therapy, and surgical interventions to reduce symptoms and prevent complications.PreventionPrevention of mitral stenosis primarily focuses on reducing the incidence of bacterial infections, particularly streptococcal infections, which can lead to rheumatic fever and subsequent valvular damage. Timely...
532

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Procedural Strategies for Optimal Transcatheter Aortic Valve Replacement: An International Position Statement.

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Related Experiment Video

Updated: Apr 30, 2026

Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation
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Upper-extremity Approach for Secondary Access in Transfemoral Transcatheter Aortic Valve Implantation

Published on: August 8, 2025

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Expanding indications for transcatheter aortic valve replacement.

Gabriel Maluenda1, Danny Dvir

  • 1Cardiovascular Center, Hospital San Borja Arriaran, School of Medicine, University of Chile, Santiago, Chile.

Expert Review of Cardiovascular Therapy
|May 10, 2014
PubMed
Summary

Transcatheter aortic valve replacement (TAVR) is established for inoperable patients with severe aortic stenosis (AS). This review examines TAVR

Keywords:
aortic regurgitationaortic stenosisbicuspid aortic stenosismoderate risktranscatheter aortic valve replacementvalve-in-valve

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Technique and Patient Selection Criteria of Right Anterior Mini-Thoracotomy for Minimal Access Aortic Valve Replacement
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Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Medical Technology

Background:

  • Transcatheter aortic valve replacement (TAVR) is a standard treatment for severe symptomatic aortic stenosis (AS) in non-operable and high-risk surgical patients.
  • The application of TAVR in alternative indications beyond standard high-risk AS is an evolving area with limited evidence.

Purpose of the Study:

  • To review the current evidence for TAVR in potential indications beyond high-risk/non-operable severe symptomatic native aortic valve stenosis.
  • To provide updated results from clinical trials and registries investigating these alternative TAVR indications.
  • To offer practical recommendations for TAVR use in these specific patient groups.

Main Methods:

  • Systematic review of current clinical trial data and registry outcomes.
  • Analysis of safety and efficacy data for TAVR in various non-standard indications.
  • Synthesis of evidence to formulate clinical recommendations.

Main Results:

  • TAVR is well-established for non-operable and high-risk severe symptomatic AS.
  • Evidence for TAVR in other indications is still emerging, with ongoing trials and registries.
  • Specific patient subsets show promise for TAVR, requiring careful consideration of available data.

Conclusions:

  • TAVR's role is expanding beyond its initial indications for aortic stenosis.
  • Further research and data collection are crucial for defining TAVR's efficacy and safety in new patient populations.
  • Practical guidelines are needed to support the appropriate use of TAVR in evolving clinical scenarios.