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ANK3 gene expression in bipolar disorder and schizophrenia
Katrine Verena Wirgenes1, Martin Tesli1, Elin Inderhaug1
1Katrine Verena Wirgenes, MD, Martin Tesli, MD, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, and Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway; Elin Inderhaug, BSc, Lavinia Athanasiu, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, and Division of Mental Health & Addiction and Department of Medical Genetics, Oslo University Hospital, Oslo, Norway; Ingrid Agartz, MD, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo; Division of Mental Health and Addiction, Oslo University Hospital; and Department of Psychiatric Research, Diakonhjemmet Hospital, Oslo, Norway; Ingrid Melle, MD, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, and Division of Mental Health and Addiction, Oslo University Hospital; Timothy Hughes, PhD, Department of Medical Genetics, Oslo University Hospital; Ole Andreas Andreassen, MD, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, and Division of Mental Health and Addiction, Oslo University Hospital; Srdjan Djurovic, PhD, NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, and Department of Medical Genetics, Oslo University Hospital, Oslo, Norway.
Ankyrin-3 (ANK3) gene expression in blood is elevated in bipolar disorder and schizophrenia. This suggests ANK3 mRNA may serve as a valuable biomarker for understanding these psychotic disorders.
Area of Science:
- Neuroscience
- Genetics
- Psychiatry
Background:
- Ankyrin-3 (ANK3) gene variants are linked to bipolar and schizophrenia spectrum disorders.
- The specific role of the ankyrin-3 protein in these conditions is not well understood.
Purpose of the Study:
- To investigate the expression levels of ANK3 in individuals with bipolar disorder and schizophrenia.
- To explore potential genetic regulatory mechanisms influencing ANK3 expression.
Main Methods:
- Gene expression analysis in blood samples from patients and healthy controls.
- Identification of potential cis-acting expression quantitative trait loci (eQTLs) near the ANK3 gene.
Main Results:
- Significantly increased ANK3 gene expression was observed in bipolar disorder and schizophrenia patients compared to healthy controls.
- Potential cis-acting eQTLs were identified near the transcription start site of an ANK3 isoform.
Conclusions:
- ANK3 mRNA levels are altered in the blood of individuals with bipolar disorder and schizophrenia.
- These findings highlight ANK3 mRNA as a potential biomarker for further research into the pathophysiology of psychotic disorders.
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