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Related Concept Videos

Imaging Studies II: Positron Emission Tomography and Scintigraphy01:25

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Positron Emission Tomography (PET) is a medical imaging technique that provides crucial insights into the body's physiological functions at a molecular level. It is an indispensable resource for diagnosing, staging, and monitoring various illnesses, notably cancer, neurological disorders, and cardiovascular conditions.
Fundamental Principles of PET
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Multiple Sclerosis l: Introduction01:19

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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Positron Emission Tomography01:29

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Positron emission tomography (PET) is a medical imaging technique involving radiopharmaceuticals — substances that emit short-lived radiation. Although the first PET scanner was introduced in 1961, it took 15 more years before radiopharmaceuticals were combined with the technique and revolutionized its potential.
One of the main requirements of a PET scan is a positron-emitting radioisotope, which is produced in a cyclotron and then attached to a substance used by the part of the body...
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Related Experiment Video

Updated: Apr 30, 2026

Positron Emission Tomography Imaging for In Vivo Measuring of Myelin Content in the Lysolecithin Rat Model of Multiple Sclerosis
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PET imaging in multiple sclerosis.

Daniele de Paula Faria1, Sjef Copray, Carlos Buchpiguel

  • 1Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.

Journal of Neuroimmune Pharmacology : the Official Journal of the Society on Neuroimmune Pharmacology
|May 10, 2014
PubMed
Summary

Positron emission tomography (PET) offers advanced imaging for multiple sclerosis (MS) by tracking disease processes. Further research into novel PET tracers could significantly expand its clinical applications for MS patients.

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Area of Science:

  • Neuroimaging
  • Medical Diagnostics
  • Biochemistry

Background:

  • Positron emission tomography (PET) is a non-invasive quantitative imaging technique.
  • PET utilizes radiolabeled tracers to visualize biological processes.
  • Current PET applications in multiple sclerosis (MS) are limited.

Purpose of the Study:

  • To review existing PET imaging studies in multiple sclerosis.
  • To identify unexplored targets and processes for PET in MS research.
  • To highlight potential future clinical applications of PET in MS.

Main Methods:

  • Review of published literature on PET imaging in multiple sclerosis.
  • Analysis of current clinical and preclinical PET applications.
  • Identification of novel PET tracers and targets relevant to MS.

Main Results:

  • Clinical PET studies in MS primarily focus on glucose metabolism and neuroinflammation (microglia/macrophages).
  • Preclinical studies have explored PET for demyelination and remyelination.
  • Numerous potential PET tracers for MS remain uninvestigated.

Conclusions:

  • PET imaging has a limited but growing role in multiple sclerosis research.
  • Expanding PET applications to include demyelination, remyelination, and other targets is promising.
  • Further investigation of novel PET tracers could revolutionize MS diagnostics and monitoring.