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Updated: Apr 30, 2026

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Y-27632 Enriches the Yield of Human Melanocytes from Adult Skin Tissues
Published on: July 8, 2020
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Vemurafenib-related cutaneous side effects ameliorated by acitretin
Journal of Drugs in Dermatology : JDD
|May 10, 2014
Summary
Acitretin may help prevent and slow the growth of skin neoplasms, such as squamous cell carcinomas, that can develop as a side effect of vemurafenib therapy for metastatic melanoma.
Area of Science:
- Oncology
- Dermatology
- Pharmacology
Background:
- Vemurafenib, a BRAF inhibitor, treats metastatic melanoma with V600E BRAF mutation.
- Common side effects include squamous cell carcinomas (SCCs) and keratoacanthomas (KAs).
- Systemic retinoids like acitretin are used for chemoprophylaxis against non-melanoma skin cancers.
Observation:
- Two stage IV metastatic melanoma patients developed numerous hyperkeratotic neoplasms within one month of starting vemurafenib.
- Acitretin treatment was initiated for these patients.
- A significant reduction in new neoplasms was observed after one month of acitretin therapy.
Findings:
- Acitretin use correlated with a decrease in vemurafenib-associated neoplasms.
- The drug appeared to slow the progression of aggressive SCCs and KAs.
Implications:
- Acitretin may serve a chemopreventive role for specific patients experiencing rapid neoplasm development during vemurafenib treatment.
- Further research into acitretin could reduce vemurafenib-related side effects and improve patient outcomes.
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