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Alpha-interferon therapy for lymphoproliferative disorders developing in two children following bone marrow
M E Trigg1, P de Alarcon, S Rumelhart
1Department of Pediatrics, University of Iowa Hospitals and Clinics, Iowa City 52242.
Abstract:
Two children developed lymphoproliferative processes following marrow transplantation. One of the two lymphoproliferative processes was documented to be Epstein-Barr virus (EBV)-associated. Both children received an extended course of alpha-interferon and gammaglobulin and responded with the disappearance of the lymphoproliferative process. Side effects from the alpha-interferon were minimal. Previous experience with EBV-associated lymphoproliferative processes following marrow transplantation have been usually fatal. This report further substantiates that alpha-interferon has a role in the treatment of EBV-associated lymphoproliferative processes following marrow transplantation.