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Published on: September 17, 2014
Patented pulsatile drug delivery technologies for chronotherapy.
Sumit S Patil1, Aliasgar Shahiwala
1Sainath University, Department of Pharmaceutical Sciences , Ranchi , India.
Pulsatile drug delivery systems offer programmable drug release after a specific lag time, addressing chronotherapy needs. Innovations focus on barrier coatings and capsular structures for advanced drug delivery.
Area of Science:
- Pharmaceutical Technology
- Drug Delivery Systems
- Chronopharmaceutics
Background:
- Advanced oral drug delivery systems, including zero-order sustained-release kinetics, meet complex therapeutic demands.
- Chronobiology principles are increasingly integrated into medicine, driving innovation in pulsatile drug delivery systems for chronotherapy.
- Pulsatile drug delivery systems are crucial for addressing specific chronotherapy requirements.
Purpose of the Study:
- To review and highlight innovations in pulsatile drug delivery systems.
- To discuss recent patents and developments in the field of pulsatile drug delivery.
- To assess the novelty and feasibility of emerging technologies in pulsatile drug delivery.
Main Methods:
- In-depth review of recent patents and developments in pulsatile drug delivery.
- Focus on systems with eroding, soluble, or rupturable barrier coatings.
- Analysis of capsular structure-based pulsatile drug delivery systems.
Main Results:
- Significant growth in patent publications for pulsatile drug delivery systems since 1981.
- Numerous advancements in drug delivery technologies for pulsatile systems have been observed.
- Emerging technologies show promise for future pulsatile drug delivery applications.
Conclusions:
- Pulsatile delivery, characterized by a programmable lag phase, is gaining interest.
- Future chronotherapeutic medications necessitate integration with hydrogel and transdermal systems.
- Selection of chronopharmaceutical technology should prioritize manufacturing ease and cost-effectiveness.
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