Related Experiment Video
Updated: Apr 30, 2026

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
Published on: March 10, 2020
Congenital heart defects and maternal fever: systematic review and meta-analysis
1Tianjin Second People's Hospital, School of Graduate, Tianjin Medical University, Tianjin, China.
Objective:
To systematically review and meta-analyze the relation between maternal fever in the first trimester and congenital heart defect (CHD) in offspring.
Study Design:
We searched PubMed (1977-2012), Embase (1974-2012) and the Cochrane Library (2012) databases to identify relevant articles. Random effects model were performed, with the conduction of subgroup analysis.
Result:
Meta-analysis yielded a pooled odds ratio of 1.53 (95% confidence interval=1.36 to 1.73) for the magnitude of the relation between maternal fever in the first trimester and CHD in offspring. As to subgroup analysis, it is associated with ventricular septal defects (VSDs) and right obstructive defects.
Conclusion:
Our analysis suggests that maternal fever in the first trimester is the risk factor of congenital heart diseases in offspring. Through the subgroup analysis, we find that exposure to maternal fever is the risk factor of VSD and right obstructive defects.
More Related Videos
Related Concept Videos
Rheumatic Heart Disease I: Introduction
Teratogenicity
Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies
Fetal Circulation
Two umbilical arteries transport blood from the fetus to the placenta. At the placenta, the blood absorbs oxygen and nutrients while simultaneously eliminating waste products. This oxygen-enriched and nutrient-rich blood then returns to the fetus through one...
Increased Body Temperature
Methods of reducing fever
Pharmacological Methods of Reducing Fever:

