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Updated: Apr 30, 2026

Rapid Screening of HIV Reverse Transcriptase and Integrase Inhibitors
Published on: April 9, 2014
Polymers fight HIV: potent (pro)drugs identified through parallel automated synthesis
Kaja Zuwala1, Anton A A Smith, Almar Postma
1Department of Chemistry, Aarhus University, Aarhus, C 8000, Denmark; Department of Infectious Diseases, Aarhus University Hospital, Denmark.
Abstract:
Macromolecular (pro)drugs interfere with the proliferation of HIV through both inhibition of viral cell entry and via intracellular delivery of antiviral drugs. Lead polymer conjugates exhibit longevity of action exceeding that of parent nucleoside analogue drug and are active in primary T cell over at least 72 h.
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