Related Experiment Video
Updated: Apr 30, 2026
Establishment of Hepatocarcinoma in BALB/c-nu Mice and Investigation of the Therapeutic Effect of the Sanleng Jiashen Formula
Published on: January 26, 2024
Hepatoprotective coumarins and secoiridoids from Hydrangea paniculata
Jing Shi1, Chuang-Jun Li2, Jing-Zhi Yang2
1State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Department of Pharmaceutics, Shandong Cancer Hospital and Institute, Shandong Academy of Medical Sciences, Jinan 250117, China.
Abstract:
Three new coumarin glucosides (1, 3, 4), and a new secoiridoid glucoside (2), together with one known secoiridoid glucoside (5), were isolated from the stems of Hydrangea paniculata. Their structures were elucidated on the basis of spectroscopic methods, including extensive NMR, MS and CD spectra. At 10 μM, compounds 1-5 showed hepatoprotective activities against DL-galactosamine-induced toxicity in HL-7702 cells.
