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CeasIng Cpap At standarD criteriA (CICADA): impact on weight gain, time to full feeds and caffeine use

Margaret Broom1, Lei Ying2, Audrey Wright3

  • 1Department of Neonatology, Canberra Hospital, Garran, Australian Capital Territory, Australia.

Archives of Disease in Childhood. Fetal and Neonatal Edition
|May 10, 2014
PubMed

Insights

The CICADA method for discontinuing continuous positive airway pressure (CPAP) in preterm infants does not negatively impact weight gain or time to full feeds. This method may also shorten the time to cease caffeine.

Area of Science:

  • Neonatal Medicine
  • Respiratory Care
  • Clinical Trials

Background:

  • Previous randomized controlled trial (RCT) demonstrated that the CeasIng Cpap At standarD criteriA (CICADA) method reduced CPAP cessation time in preterm infants (<30 weeks gestation).
  • The study compared CICADA with gradual CPAP weaning methods.

Purpose of the Study:

  • To evaluate the effects of the CICADA method on weight gain, time to full feeds, and time to cease caffeine in preterm infants (<30 weeks gestation).
  • To provide evidence supporting the optimal method for discontinuing CPAP in this vulnerable population.

Main Methods:

  • Retrospective analysis of data from preterm infants (<30 weeks gestation) previously enrolled in an RCT.
  • Review of weight gain, time to reach full feeds, and time to cease caffeine.
  • Comparison of outcomes between the CICADA method and gradual CPAP weaning methods.

Main Results:

  • No significant difference in projected weight gain or time to reach full feeds (intention-to-treat analysis) was observed between the three methods.
  • Post hoc analysis suggested a trend towards earlier full feeds with CICADA, though not statistically significant (p=0.077).
  • Infants randomized to the CICADA method ceased caffeine significantly earlier than those on the gradual weaning method (p=0.02).

Conclusions:

  • The CICADA method for CPAP cessation in preterm infants (<30 weeks gestation) is safe regarding weight gain and time to full feeds.
  • The CICADA method may offer a benefit by reducing the time to cease caffeine in preterm infants.
  • This study substantiates CICADA as an optimal method for CPAP weaning in preterm infants.
Abstract

Keywords:
NeonatologyRespiratory

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