Related Experiment Video

Updated: Apr 30, 2026

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline
08:40

Spatial and Temporal Analysis of Active ERK in the C. elegans Germline

Published on: November 29, 2016

11.6K

[Advances in research on the MAPK signal transduction pathway of Echinococcus]

Cheng-Hua Wang, Hai-Long Lv, Yu-Feng Jiang

    Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi = Chinese Journal of Parasitology & Parasitic Diseases
    |May 13, 2014
    PubMed

    Insights

    Mitogen-activated protein kinase (MAPK) pathways regulate gene activation. This review explores MAPK signaling

    Area of Science:

    • Molecular Biology
    • Cell Signaling
    • Parasitology

    Context:

    • Mitogen-activated protein kinase (MAPK) signaling pathways are crucial for cellular functions.
    • MAPK pathways are implicated in various human diseases.
    • Echinococcus, a parasitic genus, presents unique biological processes.

    Purpose:

    • To review the current understanding of the MAPK signaling pathway's role in Echinococcus.
    • To elucidate the involvement of MAPK in the growth and development of Echinococcus.
    • To highlight recent advancements in this research area.

    Summary:

    • MAPK signaling molecules are activated by phosphorylation upon stimulation, translocating to the nucleus to regulate gene expression.
    • Emerging evidence demonstrates the involvement of the MAPK signaling pathway in the growth and development of Echinococcus.
    • This review consolidates recent findings on the intricate relationship between MAPK signaling and Echinococcus.

    Impact:

    • Provides a comprehensive overview for researchers studying parasitic diseases.
    • Identifies potential therapeutic targets within the MAPK pathway for Echinococcus control.
    • Facilitates further investigation into host-parasite interactions and parasitic development.

    More Related Videos

    Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment07:55

    Subcellular Fractionation for ERK Activation Upon Mitochondrial-derived Peptide Treatment

    Published on: September 25, 2017

    7.4K
    An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells08:54

    An Immunofluorescent Method for Characterization of Barrett’s Esophagus Cells

    Published on: July 20, 2014

    13.1K

    Related Concept Videos

    MAPK Signaling Cascades01:07

    MAPK Signaling Cascades

    Mitogen-activated protein kinase, or MAPK pathway, activates three sequential kinases to regulate cellular responses such as proliferation, differentiation, survival, and apoptosis. The canonical MAPK pathway starts with a mitogen or growth factor binding to an RTK. The activated RTKs stimulate Ras, which recruits Raf or MAP3 Kinase (MAPKKK), the first kinase of the MAPK signaling cascade. Raf further phosphorylates and activates MEK or MAP2 Kinases (MAPKK), which in turn phosphorylates MAP...
    7.3K
    Interactions Between Signaling Pathways01:19

    Interactions Between Signaling Pathways

    Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
    Convergence and divergence, and cross-talk between signaling pathways
    Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
    4.7K
    Mitogens and the Cell Cycle02:38

    Mitogens and the Cell Cycle

    Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
    6.3K
    mTOR Signaling and Cancer Progression03:03

    mTOR Signaling and Cancer Progression

    The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
    The mTOR pathway or the...
    3.6K
    Amplifying Signals via Enzymatic Cascade01:22

    Amplifying Signals via Enzymatic Cascade

    When a ligand binds to a cell-surface receptor, the receptor's intracellular domain changes shape, which may either activate its enzyme function or allow its binding to other molecules. The initial signal is amplified by most signal transduction pathways. This means that a single ligand molecule can activate multiple molecules of a downstream target. Proteins that relay a signal are most commonly phosphorylated at one or more sites, activating or inactivating the protein. Kinases catalyze...
    15.3K
    PI3K/mTOR/AKT Signaling Pathway01:22

    PI3K/mTOR/AKT Signaling Pathway

    The mammalian target of rapamycin  (mTOR) is a serine/threonine kinase that regulates growth, proliferation, and cell survival in response to hormones, growth factors, or nutrient availability. This kinase exists in two structurally and functionally distinct forms: mTOR complex 1  (mTORC1) and mTOR complex 2  (mTORC2). The first form (mTORC1) is composed of a rapamycin-sensitive Raptor and proline-rich Akt substrate, PRAS40. In contrast,  mTORC2 consists of a...
    5.1K