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Published on: June 4, 2017
[Allergen detection among 2 769 children with allergic symptoms in Ningbo area]
Insights
In a study of 2,769 children, 76% had allergic disease indicated by specific IgE. Dust mites were the most common allergen, particularly in males and during specific seasons.
Area of Science:
- Pediatric Allergy and Immunology
- Immunopathology
- Environmental Health
Context:
- Allergic diseases are a significant health concern in childhood.
- Understanding allergen prevalence is crucial for effective management.
- Ningbo Women & Children's Hospital data provides insights into regional pediatric allergies.
Purpose:
- To determine the prevalence of specific IgE in children with allergic diseases.
- To identify common allergens and their associations with demographic and seasonal factors.
- To analyze allergen-specific IgE levels in relation to disease severity.
Summary:
- A total of 2,769 children with allergic diseases were analyzed.
- The overall specific IgE positive rate was 76.0%, higher in males than females.
- Dust mites were the most prevalent allergen (33.2%), followed by milk and fungi (12.6% each).
- Significant seasonal variations in dust mite allergy and age-related differences in dust mite, milk, fungi, and egg allergies were observed.
- Elevated dust mite specific IgE levels (grades 3-6) were common.
Impact:
- Provides epidemiological data on pediatric allergic diseases in Ningbo.
- Highlights key allergens for targeted prevention and treatment strategies.
- Informs clinical practice regarding allergen testing and management in children.
Abstract:
A total of 2 769 children with allergic disease were admitted from October 2010 to December in Ningbo Women & Children's Hospital. Fourteen kinds of serum specific-IgE were detected by immunoblotting method. Among the 2 769 children, the total positive rate of sIgE was 76.0% (2 105/2 769). The sIgE positive rate in males (80.0%, 1 344/1 679) was significantly higher than that of females (69.8%, 761/1 090)(P < 0.05). The top three allergens were dust mites (33.2%), milk (12.6%) and fungi (12.6%). There were statistical differences of positive reaction to dust mites among 4 seasons (19.4%, 33.9%, 39.3%, 36.0%) (P < 0.05). Significant differences were found in the positive rates of dust mites, milk, fungi, and egg among the age groups (P < 0.05). The level of dust mite specific IgE were mainly in grade 3-6 (613/918, 66.8%).
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