Related Experiment Video
Updated: Apr 30, 2026
Characterization of Metabolic Status in Nonhuman Primates with the Intravenous Glucose Tolerance Test
Published on: November 13, 2016
The effect of propofol on intravenous glucose tolerance test in rhesus monkey
Jong Min Kim1, Jun-Seop Shin, Il Hee Yoon
1Translational Xenotransplantation Research Center, Seoul, Korea; Department of Microbiology and Immunology, Seoul National University College of Medicine, Seoul, Korea; Medical Research Institute for Infectious Diseases, Seoul National University College of Medicine, Seoul, Korea.
Background:
Many anesthetics have been shown to impair glucose metabolism and cause hyperglycemia. The aim of this study was to evaluate the effects of propofol on glucose metabolism and insulin secretion during intravenous glucose tolerance test (IVGTT) in rhesus monkey.
Methods:
Serum cortisol, blood glucose, insulin, and C-peptide concentrations during IVGTT were measured in four rhesus monkeys under either conscious state or propofol anesthesia.
Results And Conclusions:
The levels of serum cortisol significantly increased under conscious condition, whereas these levels remained constant under propofol anesthesia. In propofol group, the levels of serum insulin and C-peptide significantly increased compared with those in conscious group. Accordingly, glucose disposal capacity was significantly improved, and the time to return to basal glucose levels was shortened in propofol group. This study showed that propofol significantly increased insulin and C-peptide, and the corresponding improvement in glucose disposal may be related to reduction of serum cortisol in monkey.
