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Updated: Apr 30, 2026
07:22
Basophil Activation Test for Allergy Diagnosis
Published on: May 31, 2021
9.9K
Patient initiation and persistence with allergen immunotherapy.
Robert Anolik1, Ann Marie Schwartz2, Shiva Sajjan3
1Allergy & Asthma Specialists, Bluebell, Pennsylvania; Drexel University School of Medicine, Philadelphia, Pennsylvania.
Summary
Only a third of patients with allergic rhinitis initiated allergen immunotherapy (AIT) as recommended. Persistence with AIT treatment, particularly subcutaneous immunotherapy (SCIT), was higher in adults and children who completed therapy.
Area of Science:
- Allergy and Immunology
- Clinical Medicine
- Pharmacotherapy
Background:
- Allergen immunotherapy (AIT) is recommended for allergic rhinitis patients with persistent symptoms despite medication and avoidance.
- Factors influencing AIT initiation and completion are crucial for treatment success.
Purpose of the Study:
- To evaluate patient initiation and persistence rates for subcutaneous (SCIT) and sublingual (SLIT) immunotherapies.
- To assess adherence to AIT regimens based on physician recommendations.
Main Methods:
- Retrospective review of electronic health records from a large allergy practice.
- Analysis of patients with allergic rhinitis for whom AIT was recommended.
Main Results:
- 36.2% of patients initiated AIT; 78% chose SCIT, 22% chose SLIT.
- AIT initiation was linked to comorbidities like chronic sinusitis, allergic conjunctivitis, and asthma.
- Treatment completion rates were 30.2% for adults and 35.4% for children, with longer durations for SCIT.
Conclusions:
- A minority of patients initiate and complete AIT, suggesting it may be underutilized.
- AIT could benefit patients with refractory allergic rhinitis symptoms.
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