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Updated: Apr 30, 2026
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Facial Transplants in Xenopus laevis Embryos
Published on: March 26, 2014
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Experimental canine facial transplantation
1Department of Plastic and Reconstructive Surgery, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Korea.
Transplantation Proceedings
|May 13, 2014
Summary
Researchers developed a canine composite facial allograft model, finding it suitable for facial transplantation training and research due to anatomical similarities and successful early graft survival.
Area of Science:
- Surgical Innovation
- Transplantation Medicine
- Veterinary Science
Background:
- Facial allotransplantation offers novel solutions for complex facial defects.
- Developing a suitable animal model is crucial for refining surgical techniques and improving outcomes.
- Canine models are appealing due to anatomical similarities to humans in facial structure, nerve, and vascular systems.
Purpose of the Study:
- To develop and evaluate a canine model for composite facial and scalp allograft.
- To establish a standardized training and research platform for facial transplantation.
Main Methods:
- Simultaneous operative teams harvested hemifacial/scalp flaps and prepared recipients.
- Flaps were transferred with major vessels (carotid artery, jugular vein).
- Vascular anastomosis included external jugular vein and external carotid artery to lingual artery.
Main Results:
- Mean transplantation time was 5 hours 30 minutes.
- Animals received FK-506 (tacrolimus) for 7 days post-surgery.
- Most allografts demonstrated excellent viability with no early vascular complications.
Conclusions:
- The canine composite facial allograft model is well-qualified for transplantation training.
- This model provides a valuable platform for future facial transplantation research.
- The study highlights the feasibility and potential of this animal model.
