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Analyses of Mitochondrial Calcium Influx in Isolated Mitochondria and Cultured Cells
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ERp57 modulates mitochondrial calcium uptake through the MCU.

Jingquan He1, Weikang Shi1, Yu Guo1

  • 1State Key Laboratory of Biomembrane and Membrane Biotechnology, College of Life Sciences, Peking University, Beijing 100871, China.

FEBS Letters
|May 13, 2014
PubMed
Summary

The protein ERp57 regulates mitochondrial calcium uptake by controlling the expression of the mitochondrial calcium uniporter (MCU). Silencing ERp57 reduces MCU levels and inhibits calcium uptake.

Keywords:
ERp57MCUMitochondrial calcium uptake

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