Related Experiment Video
Updated: Apr 30, 2026
09:12
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods
Published on: May 11, 2018
6.6K
Production and applications of engineered viral capsids
Jeff Glasgow1, Danielle Tullman-Ercek
1Department of Chemistry, University of California Berkeley, Berkeley, CA, 94720, USA.
Applied Microbiology and Biotechnology
|May 13, 2014
Summary
Viral capsids, protein shells of viruses, can be engineered for precise applications. This review covers methods for manipulating viral capsid properties and their diverse uses in biotechnology, nanotechnology, and medicine.
Area of Science:
- Biotechnology
- Nanotechnology
- Virology
- Materials Science
Background:
- Viruses are biological agents with diverse sizes, shapes, and surface structures.
- Viral capsids are protein assemblies that can be precisely engineered.
- Homogeneous capsid populations are crucial for consistent therapeutic and material properties.
Purpose of the Study:
- To review methods for producing and manipulating viral and virus-like particles.
- To explore applications of engineered viral capsids in various scientific fields.
- To discuss the potential of engineered capsids for commercial and therapeutic products.
Main Methods:
- Review of current literature on viral capsid production and engineering.
- Analysis of techniques for controlling capsid size, surface chemistry, and assembly.
- Examination of methods for manipulating interior cargo within capsids.
Main Results:
- Viral capsid engineering allows for precise control over size, surface chemistry, and assembly.
- Engineered capsids can be tailored for specific applications in biotechnology and nanotechnology.
- Methods exist to manipulate the interior cargo of viral capsids for targeted delivery.
Conclusions:
- Engineered viral capsids offer versatile platforms for advanced applications.
- Further research into capsid manipulation can lead to novel therapeutics and materials.
- The precise, self-assembling nature of viral capsids makes them ideal for nanotechnology and medicine.
More Related Videos
08:40Production of Pseudotyped Particles to Study Highly Pathogenic Coronaviruses in a Biosafety Level 2 Setting
Published on: March 1, 2019
60.1K
08:14Combined Genetic and Chemical Capsid Modifications of Adenovirus-Based Gene Transfer Vectors for Shielding and Targeting
Published on: October 26, 2018
8.0K
Related Concept Videos
00:56Viral Structure
58.9K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
58.9K
01:28Introduction to Virus
2.9K
Viruses are unique biological entities that blur the boundary between living and non-living systems. Although they lack cellular structure and metabolic processes, they can exhibit characteristics of life when infecting a host. Their defining feature is a nucleic acid core, composed of either DNA or RNA, encapsulated within a protein coat called a capsid. This simple structure allows them to invade host cells and use their machinery for replication efficiently.Viral Structure and...
2.9K
01:29Subviral Agents
929
Subviral agents are infectious entities that resemble viruses but lack one or more viral components, such as a capsid or essential replication machinery. These agents include viroids, prions, and satellites, each possessing distinct structural and functional characteristics that influence their mode of infection and replication.Viroids are the simplest subviral agents, consisting of circular, single-stranded RNA molecules without a protein coat. They exclusively infect plants, relying entirely...
929
00:50What are Viruses?
109.5K
Overview
109.5K
02:33Retroviruses
12.0K
Retroviruses and retrotransposons both insert copies of their genetic elements into the genome of the host cell. Thus, the viral genes are passed on when the host genome is replicated or translated. A typical retroviral DNA sequence contains 3-4 genes that encode the different proteins required for its structural assembly and function as a molecular parasite. This DNA is transcribed into a single mRNA, which is very similar in structure to conventional mRNAs, i.e., it is capped at the 5’...
12.0K
01:26Size and Structure of Viral Genomes
1.2K
Viral genomes exhibit remarkable diversity in size, structure, and composition, influencing their replication strategies and interactions with host cells. These genomes consist of either DNA or RNA and may be linear or circular. Additionally, they can be single-stranded or double-stranded, with each configuration affecting how the virus propagates within a host. RNA viruses, for instance, generally have smaller genomes than DNA viruses, a factor that contributes to their high mutation rates and...
1.2K