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Published on: October 5, 2019
Spontaneous biomimetic formation of (±)-dictazole B under irradiation with artificial sunlight
Adam Skiredj1, Mehdi A Beniddir, Delphine Joseph
1Laboratoire de Pharmacognosie associé au CNRS, UMR 8076 BioCIS, LabEx LERMIT, Université Paris-Sud, 5, rue Jean-Baptiste Clément, 92296 Châtenay-Malabry (France) http://www.biocis.u-psud.fr.
Abstract:
Guided by biosynthetic considerations, the total synthesis of dictazole B is reported for the first time. Experimental evidence for an easy access to challenging cyclobutane alkaloids of marine origin, which are often postulated to be biosynthetic precursors of more complex structures, is provided.
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