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Published on: February 7, 2019
Bioinspired total synthesis of (dibromo)sceptrin and (dibromo)ageliferin
Mohammed Latrache1, Amina Sesay1, Samuel Oger1
1BioCIS, CNRS, Université Paris-Saclay, 91400, Orsay, France. laurent.evanno@universite-paris-saclay.fr.
Abstract:
We report a bioinspired synthesis of the emblematic marine alkaloids sceptrin, dibromosceptrin, ageliferin and dibromoageliferin. Central to this approach is a photocatalytic dimerization of fully elaborated precursors via [2+2] or [4+2] cycloadditions in batch and in flow. Notably, this work constitutes the first total syntheses of these natural products achieved by direct assembly of the native hymenidin and oroidin frameworks.
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