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LC-MS/MS quantitative analysis of quorum sensing signal molecules

Catharine A Ortori1, Nigel Halliday, Miguel Cámara

  • 1Centre for Analytical Bioscience, School of Pharmacy, University of Nottingham, University Park, Nottingham, NG7 2RD, UK.

Methods in Molecular Biology (Clifton, N.J.)
|May 14, 2014
PubMed
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Quorum sensing is a mechanism of bacterial communication that enables coordinated gene expression in response to changes in population density. This facilitates collective behaviors that enhance survival, resource acquisition, and ecological adaptation. This process relies on small signaling molecules called autoinducers that accumulate as bacterial populations grow. When a critical threshold concentration of autoinducers is reached, bacterial cells collectively modify gene expression,...
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