Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Blood Transfusion and Agglutination02:45

Blood Transfusion and Agglutination

12.8K
Blood transfusion is a therapeutic measure to restore the blood volume after extensive blood loss due to an accident or a medical procedure. Blood transfusion involves drawing a certain amount of blood from a suitable donor and infusing it into the recipient.
History
The history of blood transfusion dates back to the 17th century, when early attempts were made in animals. In 1818 James Blundell, a British doctor, performed the first successful human blood transfusion. Later in 1900, Karl...
12.8K
Blood Transfusion01:15

Blood Transfusion

3.0K
Blood transfusion is a critical medical procedure that saves lives and treats various medical conditions. It involves transferring blood from a donor to a recipient. This process requires a thorough understanding of the ABO blood group system and its associated antigens and antibodies.
Blood Transfusion Overview
A blood transfusion is a medical procedure used to replace blood lost due to injury, surgery, or to treat conditions such as anemia or cancer. During a transfusion, donor blood is...
3.0K
Blood Typing01:10

Blood Typing

5.9K
Understanding an individual's blood group is a critical component of transfusion medicine. It ensures compatibility in blood transfusions, organ transplants, and even during pregnancy. Determining these blood groups involves the ABO and Rh blood typing systems, utilizing specific antigens and corresponding anti-sera to identify an individual's blood type.
Antigens are protein molecules that reside on the surface of red blood cells (RBCs). The ABO and Rh blood typing systems target...
5.9K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

3.0K
Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
3.0K
Blood Types02:20

Blood Types

18.1K
Human blood is classified into different types based on the presence of antigens on the red blood cell's surface and antibodies in the plasma. Proper identification of blood type is essential for successful blood transfusion. The International Society of Blood Transfusion has identified 38 human blood types based on the surface antigens on the red blood cells. The most common types are ABO, Rh, and MNS blood types.
ABO blood group
ABO antigens are glycoproteins encoded by genes present on...
18.1K
Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

2.6K
Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
2.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hemopexin Purification From Human Cohn Fraction IV Paste and Its Biophysical Characterization and Functional Evaluation in Sickle Cell Disease Mice.

Biotechnology and bioengineering·2026
Same author

Hemoglobin-based oxygen carriers with antioxidant properties.

Journal of materials chemistry. B·2026
Same author

Separation of intrinsically magnetic cells using magnetic filters.

Separation and purification technology·2026
Same author

Sex determines cardiac and renal Vulnerability to chronic hemoglobin toxicity.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie·2026
Same author

Dissolved Oxygen-Dependent Magnetophoresis of Sickle Red Blood Cells and Proof-of-Concept Separation Using a Magnetic Column.

ACS measurement science au·2026
Same author

Acellular Hemoglobin Impairs Cardiomyocyte Excitation-Contraction Coupling.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·2026
Same journal

Physics-Informed Machine Learning in Biomedical Science and Engineering.

Annual review of biomedical engineering·2026
Same journal

Advancements and Challenges in Computer-Assisted Medical Interventions for Image-Guided Prostate Cancer Treatments.

Annual review of biomedical engineering·2026
Same journal

Recent Advances in mRNA Therapeutic Cancer Vaccines.

Annual review of biomedical engineering·2026
Same journal

Artificial Intelligence-Based Analysis of Laparoscopic Imaging for Intraoperative Surgical Decision Support.

Annual review of biomedical engineering·2026
Same journal

Viscoelasticity of the Heart: An Overview of Viscoelastic Measurements at Different Scales.

Annual review of biomedical engineering·2026
Same journal

Digital Twins for Biofluids.

Annual review of biomedical engineering·2026
See all related articles

Related Experiment Video

Updated: Apr 30, 2026

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

9.1K

Blood substitutes.

Andre F Palmer1, Marcos Intaglietta

  • 1William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, Ohio 43210;

Annual Review of Biomedical Engineering
|May 14, 2014
PubMed
Summary
This summary is machine-generated.

New hemoglobin-based oxygen therapeutics offer potential for treating ischemia and trauma. While current limitations exist, coformulation with antioxidants enhances their efficacy and therapeutic benefits.

Keywords:
oxygen therapeuticsplasma expanderspoly(ethylene glycol)-conjugated hemoglobinpolymerized hemoglobinred blood cell substitutessupraperfusionvesicle-encapsulated hemoglobin

More Related Videos

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

18.8K
Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

17.6K

Related Experiment Videos

Last Updated: Apr 30, 2026

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro
10:25

Microfluidic Flow Chambers Using Reconstituted Blood to Model Hemostasis and Platelet Transfusion In Vitro

Published on: March 19, 2016

9.1K
Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload
05:23

Continuous Manual Exchange Transfusion for Patients with Sickle Cell Disease: An Efficient Method to Avoid Iron Overload

Published on: March 14, 2017

18.8K
Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols
11:31

Antigens Protected Functional Red Blood Cells By The Membrane Grafting Of Compact Hyperbranched Polyglycerols

Published on: January 2, 2013

17.6K

Area of Science:

  • Biomedical Engineering
  • Hematology
  • Pharmacology

Background:

  • Early red blood cell substitutes faced challenges with toxic side effects.
  • Development has shifted towards advanced hemoglobin-based oxygen carriers (HBOCs).
  • New HBOCs include polymerized, PEG-conjugated, and vesicle-encapsulated hemoglobins.

Purpose of the Study:

  • To evaluate the therapeutic potential of advanced HBOCs.
  • To address limitations of current HBOCs regarding oxygen-carrying capacity.
  • To explore additional therapeutic benefits of HBOCs in treating ischemia and trauma.

Main Methods:

  • Development of novel hemoglobin-based oxygen therapeutics.
  • Formulation strategies including coformulation with antioxidants.
  • Assessment of colloid osmotic pressure and plasma viscosity.
  • Evaluation of oxygen-carrying and delivery capabilities.
  • Investigation of plasma expansion properties and systemic effects.

Main Results:

  • Advanced HBOCs exhibit high colloid osmotic pressure and plasma viscosity, limiting full oxygen restoration.
  • These therapeutics show promise for treating ischemia and trauma, especially when coformulated with antioxidants.
  • Optimal plasma expansion properties induce supraperfusion, increasing nitric oxide production.
  • Improved tissue washout of metabolic wastes contributes to therapeutic effects.

Conclusions:

  • Advanced hemoglobin-based oxygen therapeutics offer a promising avenue for treating conditions like ischemia and trauma.
  • Coformulation with antioxidants and leveraging plasma expansion properties can enhance therapeutic efficacy.
  • Further research into optimizing HBOCs is crucial for clinical translation.