Related Experiment Video

Updated: Apr 30, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
08:10

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation

Published on: July 20, 2022

2.8K

Usefulness of left ventricular diastolic function to predict recurrence of atrial fibrillation in patients with

Taishi Hirai1, George Cotseones1, Nader Makki2

  • 1Department of Medicine, Loyola University Chicago, Stritch School of Medicine, Loyola University Medical Center, Maywood, Illinois.

The American Journal of Cardiology
|May 14, 2014
PubMed

Insights

Left ventricular diastolic dysfunction (LVDD) severity before atrial fibrillation (AF) ablation did not predict recurrence. However, an elevated E/e

Area of Science:

  • Cardiology
  • Electrophysiology
  • Echocardiography

Background:

  • Left ventricular diastolic dysfunction (LVDD) is a common comorbidity in patients with atrial fibrillation (AF).
  • The relationship between LVDD severity and AF recurrence after catheter ablation in patients with preserved left ventricular ejection fraction (LVEF) remains unclear.
  • Understanding this relationship can help optimize patient selection and post-ablation management.

Purpose of the Study:

  • To investigate the association between pre-ablation LVDD severity and AF recurrence in patients with normal LVEF.
  • To identify specific echocardiographic and Doppler indexes of LVDD that predict AF recurrence post-ablation.

Main Methods:

  • A cohort of 198 patients with normal LVEF undergoing AF ablation was retrospectively analyzed.
  • Echocardiographic and Doppler parameters assessing LVDD were measured within one year prior to ablation.
  • AF recurrence was monitored over a 12-month follow-up period.

Main Results:

  • No significant difference in conventional LVDD indexes was found between patients with and without AF recurrence.
  • Patients with an average E/e' ratio greater than 13 exhibited a significantly higher rate of AF recurrence (67% vs 35%).
  • The odds ratio for recurrence in patients with E/e' >13 was 3.70 (95% CI 1.21-11.3, p<0.05).

Conclusions:

  • Conventional echocardiographic indexes of LVDD do not predict AF recurrence after catheter ablation in patients with preserved LVEF.
  • An elevated average E/e' ratio (>13), indicative of increased left atrial pressure, is associated with a higher risk of AF recurrence.
  • The E/e' ratio may serve as a valuable marker for identifying patients at increased risk of AF recurrence post-ablation.

More Related Videos

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats08:09

Echocardiographic Assessment of Cardiac Anatomy and Function in Adult Rats

Published on: December 13, 2019

24.4K
Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice08:21

Biventricular Assessment of Cardiac Function and Pressure-Volume Loops by Closed-Chest Catheterization in Mice

Published on: June 15, 2020

6.2K

Related Concept Videos

Aortic Regurgitation III: Medical Management01:25

Aortic Regurgitation III: Medical Management

Aortic regurgitation (AR) is when the aortic valve does not close or seal properly, leading to backward blood circulation from the aorta into the left ventricle during diastole. Common causes of AR include rheumatic heart disease, congenital valve defects, and aortic root dilation. Managing AR requires a multifaceted approach to alleviate symptoms, preserve left ventricular function, and address the underlying cause of the regurgitation. Patients with symptomatic AR or significant left...
598
Aortic Regurgitation II: Clinical Features and Diagnostic Tests01:22

Aortic Regurgitation II: Clinical Features and Diagnostic Tests

Aortic valve regurgitation (AR) occurs when the aortic valve fails to close properly, allowing blood to flow backward from the aorta into the left ventricle. This backflow can result in two distinct clinical presentations: acute and chronic AR, each characterized by its own set of symptoms and physical findings.Acute Aortic RegurgitationAcute AR presents with a sudden onset of severe symptoms. Patients typically experience profound dyspnea (shortness of breath), chest pain, and signs of left...
1.2K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.8K
Mitral Regurgitation II: Clinical Features and Diagnostic Tests01:23

Mitral Regurgitation II: Clinical Features and Diagnostic Tests

Mitral regurgitation (MR) is a valvular heart disorder in which the mitral valve fails to close tightly, allowing blood to leak backward into the heart. Understanding the clinical manifestations, assessment, diagnostic findings, and medical management of MR is crucial to effectively managing affected patients.Clinical Manifestations of Mitral RegurgitationMitral regurgitation can be acute or chronic, each presenting differently and requiring different approaches:1. Acute Mitral...
943
Mitral Regurgitation I: Introduction01:20

Mitral Regurgitation I: Introduction

Mitral regurgitation is characterized by the backward circulation of blood from the left ventricle to the left atrium during systole, a phase of the cardiac cycle when the heart contracts and pumps blood out of the chambers. This abnormal flow occurs primarily due to the dysfunction of the mitral valve or its supporting structures, which include the mitral leaflets, chordae tendineae, annulus, and papillary muscles.Etiology and Mechanisms:Primary Mitral Regurgitation: This type arises from...
1.3K