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Updated: Apr 29, 2026

Using Eggs from Schistosoma mansoni as an In vivo Model of Helminth-induced Lung Inflammation
Published on: June 5, 2012
[Research progress on the role of schistosomiasis in regulating autoimmune and allergic diseases]
Abstract:
Schistosome infection down-regulates the Th1 cell-mediated autoimmune diseases and Th2 cell-mediated allergic diseases. It was revealed recently that a novel pathogenic T cell subset (Th17) was also involved in the pathogenicity of autoimmune and inflammatory diseases, and schistosome infection was reported to suppress Th17 response in autoimmune diseases. Here we summarize research advances on the effect of schistosome infection on Th1-, Th2-, Th17-mediated autoimmune or allergic diseases, and discuss the possible mechanisms of schistosome-induced suppression.
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