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The impact of age on prefrontal cortex integrity during spatial working memory retrieval

Max Toepper1, Hans J Markowitsch2, Helge Gebhardt3

  • 1Ev. Hospital Bielefeld (EvKB), Department of Psychiatry and Psychotherapy Bethel, Research Department, Remterweg 69-71, D-33617 Bielefeld, Germany; Justus-Liebig-University of Giessen, Cognitive Neuroscience at Centre for Psychiatry (CNS@ZPG), Am Steg 28, D-35392 Giessen, Germany.

Neuropsychologia
|May 15, 2014
PubMed
Summary

As we age, spatial working memory declines due to reduced brain activation and connectivity, particularly in the prefrontal cortex. Better memory performance in older adults correlates with stronger prefrontal activation and connections.

Keywords:
AgingCognitive controlDorsolateral prefrontal cortexFunctional connectivityRetrievalWorking memory

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