Landau-Kleffner syndrome with unilateral EEG abnormalities--two cases from Beijing, China

We reported 2 cases of Landau-Kleffner syndrome from Beijing whose clinical manifestations were very similar to ones previously reported. The onset of symptoms in these 2 cases was at 3 and 4 years of age, respectively, and both were characterised by unilateral focal epileptiform EEG discharges, without remarkable clinical seizures. One patient had normal SPECT study in addition to normal CT scan, BAER and VER results; the other had a family history of epilepsy. Since this syndrome may involve a primary brain disturbance responsible for both the epilepsy and aphasia without clear structural brain lesions, we wonder whether it can be classified as one of the benign functional partial epilepsies with genetic factors.