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Perceived weight discrimination and C-reactive protein
Angelina R Sutin1, Yannick Stephan, Martina Luchetti
1Florida State University College of Medicine, Tallahassee, Florida, USA.
Obesity (Silver Spring, Md.)
|May 16, 2014
Summary
Weight discrimination is linked to higher inflammation markers, specifically C-reactive protein (CRP). This association is strongest for individuals with overweight or obesity, but not for those with severe obesity.
Area of Science:
- Health outcomes research
- Physiological markers of health
- Social determinants of health
Background:
- Perceived weight discrimination is associated with adverse health outcomes, including obesity.
- The relationship between weight discrimination and physiological markers like systemic inflammation is not well understood.
Purpose of the Study:
- To examine the association between weight discrimination and C-reactive protein (CRP).
- To determine if body mass index (BMI) moderates the relationship between weight discrimination and CRP.
Main Methods:
- Cross-sectional study utilizing data from the Health and Retirement Study.
- Regression analysis was performed on 7,394 overweight or obese participants.
- Investigated associations between weight discrimination, CRP, and BMI, and tested moderation by BMI.
Main Results:
- The association between weight discrimination and CRP levels was dependent on BMI.
- Weight discrimination was linked to higher CRP in individuals with BMI between 25-30 (overweight).
- No significant association was found between weight discrimination and CRP at higher BMIs (around 40).
- A similar pattern was observed for discrimination based on physical disability, but not for other forms of discrimination.
Conclusions:
- Weight discrimination is associated with elevated circulating CRP levels.
- The association between weight discrimination and CRP is moderated by an individual's BMI.
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