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TogoTable: cross-database annotation system using the Resource Description Framework (RDF) data model.

Shin Kawano1, Tsutomu Watanabe2, Sohei Mizuguchi3

  • 1Database Center for Life Science, Research Organization of Information and Systems, 178-4-4 Wakashiba, Kashiwa, Chiba 277-0871, Japan kawano@dbcls.rois.ac.jp.

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Summary
This summary is machine-generated.

TogoTable is a web tool that enhances biological data tables with annotations from linked open data. This tool aids researchers in processing large datasets by integrating information from diverse biological databases.

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Area of Science:

  • Bioinformatics
  • Data Integration
  • Web Services

Background:

  • Biological research generates vast datasets requiring efficient data processing.
  • Integrating data from multiple biological databases is crucial for comprehensive analysis.
  • Existing tools may lack the flexibility to incorporate diverse, linked data sources.

Purpose of the Study:

  • To introduce TogoTable, a novel web tool for annotating uploaded data tables.
  • To leverage Linked Open Data (LOD) principles for enhanced data integration.
  • To provide a user-friendly platform for experimental biologists handling large-scale data.

Main Methods:

  • Developed a web tool (TogoTable) accepting user-uploaded tables.
  • Utilized Resource Description Framework (RDF) data model for annotations.
  • Employed SPARQL queries to retrieve data from SPARQL endpoints within the LOD network.
  • Used database identifiers (IDs) as keys for searching and linking annotations.

Main Results:

  • TogoTable successfully annotates user-uploaded tables with data from multiple biological databases.
  • The tool integrates annotations not only from reference databases but also from externally linked databases via LOD.
  • Demonstrated retrieval of Protein Data Bank annotations using GeneID via UniProt RDF.
  • The system is extensible to any RDF-based database.

Conclusions:

  • TogoTable offers a powerful solution for annotating and integrating biological data.
  • The tool facilitates the processing of large experimental outputs for biologists.
  • Its foundation on RDF and LOD ensures broad compatibility and future extensibility.