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Laparoscopic Splenectomy with Pericardial Devascularization for Hypersplenism and Esophageal Variceal Hemorrhage Due to Portal Hypertension
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Etiology of Portal Hypertension in Children:A Single Center's Experiences

Mohammad Hadi Imanieh1, Seyed Mohsen Dehghani2, Maryam Khoshkhui3

  • 1Professor, Gastroenterohepatology Research Center, Nemazee Teaching Hospital, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.

Middle East Journal of Digestive Diseases
|May 16, 2014
PubMed

Insights

Intrahepatic diseases are the primary cause of portal hypertension in children, accounting for 93.3% of cases. Extra-hepatic causes like portal vein thrombosis were less common in this pediatric study.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Vascular Medicine

Background:

  • Portal hypertension arises from conditions impairing portal system blood flow.
  • Identifying the etiology is crucial for effective management.
  • Previous research suggested extra-hepatic disorders as the leading cause in children.

Purpose of the Study:

  • To investigate the underlying causes of portal hypertension in pediatric patients.
  • To determine the prevalence of intrahepatic versus extra-hepatic causes in children with portal hypertension.

Main Methods:

  • Prospective, descriptive study of 45 children with portal hypertension (2005-2007).
  • Diagnostic tools included liver biopsy, abdominal sonography, CT scan, and liver Doppler sonography.
  • Etiology was determined through these investigations.

Main Results:

  • Intrahepatic diseases were identified as the cause in 42 out of 45 patients (93.3%).
  • Extra-hepatic portal hypertension, specifically portal vein thrombosis, was found in 3 patients (6.7%).

Conclusions:

  • Intrahepatic diseases represent the most frequent etiology of portal hypertension in the studied pediatric cohort.
  • Findings contrast with previous reports emphasizing extra-hepatic causes.
Abstract

Keywords:
ChildrenEtiologyExtra-hepaticIntrahepaticPortal hypertension

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