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A Network Map of FGF-1/FGFR Signaling System.

Rajesh Raju1, Shyam Mohan Palapetta2, Varot K Sandhya1

  • 1Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.

Journal of Signal Transduction
|May 16, 2014
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Summary
This summary is machine-generated.

Fibroblast growth factor-1 (FGF-1) signaling impacts cell growth and development. We created a resource detailing FGF-1/FGFR signaling pathways to aid research into its role in health and disease.

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Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • Fibroblast growth factor-1 (FGF-1) is a key signaling molecule in the FGF superfamily, regulating critical cellular functions like growth, differentiation, and survival.
  • FGF-1 interacts with all four FGF receptors (FGFRs), influencing diverse physiological processes including development, angiogenesis, and wound healing.
  • Dysregulation of FGF-1 signaling is linked to tumorigenesis, invasion, and metastasis, highlighting its biomedical significance.

Purpose of the Study:

  • To address the lack of public resources for analyzing individual FGF-induced signaling pathways.
  • To develop a comprehensive resource detailing signaling reactions triggered by the FGF-1/FGFR system.
  • To provide downloadable pathway data and reaction maps in standard formats for research use.

Main Methods:

  • Curated and compiled data on signaling reactions initiated by FGF-1 binding to its cognate receptors.
  • Developed a pathway resource integrating information across various cell types and tissues.
  • Made pathway data and reaction maps available through the NetPath and NetSlim resources.

Main Results:

  • A novel resource detailing FGF-1/FGFR signaling pathways has been established.
  • The resource includes comprehensive data on signaling reactions triggered by FGF-1.
  • Pathway data and reaction maps are accessible for download in multiple standard formats.

Conclusions:

  • The developed resource facilitates focused analysis of FGF-1/FGFR signaling pathways.
  • This resource supports research into the role of FGF-1 in physiological processes and diseases.
  • Availability of curated pathway data enhances understanding of complex cell signaling networks.