Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Synthesis and Regulation of Thyroid Hormones01:20

Synthesis and Regulation of Thyroid Hormones

8.8K
Low blood levels of the thyroid hormones — triiodothyronine (T3) and thyroxine (T4) — signal the hypothalamus to release the thyrotropin-releasing hormone (TRH). TRH then reaches the pituitary gland and stimulates the release of thyroid-stimulating hormone(TSH) into the bloodstream.
Upon reaching the thyroid gland, TSH stimulates the follicular cells' active uptake of iodide ions from the blood. The ions diffuse to the apical surface of the cells and are oxidized to iodine. The...
8.8K
Functions of Thyroid Hormones01:18

Functions of Thyroid Hormones

6.4K
The thyroid hormone (TH) plays a pivotal role in the intricate orchestration of physiological processes, exerting profound effects on development, metabolism, and homeostasis throughout different life stages.
TH is indispensable for the normal development and maturation of the skeletal, muscular, and nervous systems during fetal and childhood growth. It facilitates bone mineral turnover and regulates protein synthesis in developing tissues, contributing significantly to overall growth and...
6.4K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

5.0K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
5.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

1.6K
1.6K
Synthesis and Functions of Calcitonin00:51

Synthesis and Functions of Calcitonin

5.2K
Calcitonin, a vital polypeptide hormone, regulates calcium levels within body fluids. It is released by the parafollicular cells, also known as C cells, situated in the follicular epithelium of the thyroid gland. Calcitonin responds to fluctuations in blood calcium levels and the influence of gastrointestinal hormones like gastrin and cholecystokinin.
The exact mechanisms by which calcitonin operates in calcium homeostasis remain elusive, but its significance is evident in several vital...
5.2K
Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

8.4K
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
8.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Revisiting retinoic acid in AML therapy: mechanisms of action and rational combination strategies.

British journal of cancer·2026
Same author

Analysis of genetic risk factors for Leber hereditary optic neuropathy in the Polish population.

Journal of applied genetics·2026
Same author

A plain language summary of the final overall survival results from the TALAPRO-2 study comparing talazoparib plus enzalutamide with placebo plus enzalutamide for patients with advanced prostate cancer.

Future oncology (London, England)·2026
Same author

Detection of Gene Fusions in Soft Tissue Sarcoma Using Next-Generation Sequencing.

Genes·2026
Same author

Long-term efficacy of radical treatment of patients with clear cell sarcoma.

European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·2026
Same author

Dual-Functionality of Polysaccharide-based Hemostatic Powder: Effective Bleeding Control and Adhesion Reduction in Surgical Models.

Macromolecular bioscience·2026

Related Experiment Video

Updated: Mar 23, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

7.9K

Thyroid Hormones as Renal Cell Cancer Regulators.

Łukasz Szymański1, Damian Matak2, Ewa Bartnik3

  • 1Department of Oncology, Military Institute of Medicine, Szaserow 128, 04-141 Warsaw, Poland; Institute of Genetics and Biotechnology, Faculty of Biology, Warsaw University, Pawinskiego 5a, 02-106 Warsaw, Poland; Department of Microwave Safety, Military Institute of Hygiene and Epidemiology, Kozielska 4, 01-163 Warsaw, Poland.

Journal of Signal Transduction
|April 2, 2016
PubMed
Summary
This summary is machine-generated.

Thyroid hormone influences cancer progression. This review focuses on how thyroid hormone and its receptors regulate renal cell carcinoma, considering genomic changes and splicing.

More Related Videos

Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.4K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

2.4K

Related Experiment Videos

Last Updated: Mar 23, 2026

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice
07:02

In Vivo Inhibition of MicroRNA to Decrease Tumor Growth in Mice

Published on: August 23, 2019

7.9K
Spontaneous Murine Model of Anaplastic Thyroid Cancer
05:39

Spontaneous Murine Model of Anaplastic Thyroid Cancer

Published on: February 3, 2023

2.4K
Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma
06:08

Establishment and Characterization of Patient-Derived Xenograft Models of Anaplastic Thyroid Carcinoma and Head and Neck Squamous Cell Carcinoma

Published on: June 2, 2023

2.4K

Area of Science:

  • Endocrinology
  • Oncology
  • Molecular Biology

Background:

  • Thyroid hormone is a key regulator in cancer development and metastasis.
  • Genomic alterations and alternative splicing can modulate thyroid hormone receptor activity.
  • The mechanism of thyroid hormone action varies significantly across different cancer types.

Purpose of the Study:

  • To review the role of thyroid hormone and its receptors in regulating renal cell carcinoma (RCC).
  • To explore how genomic changes and alternative splicing impact thyroid hormone signaling in RCC.

Main Methods:

  • Literature review of studies on thyroid hormone, its receptors, and renal cell carcinoma.
  • Analysis of mechanisms underlying thyroid hormone action in cancer.
  • Examination of the interplay between genomic alterations, splicing, and thyroid hormone signaling in RCC.

Main Results:

  • Thyroid hormone and its receptors play a distinct regulatory role in renal cell carcinoma.
  • Genomic instability and alternative splicing are identified as factors influencing thyroid hormone receptor function in RCC.
  • The specific mechanisms of thyroid hormone action in RCC are complex and cancer-type dependent.

Conclusions:

  • Thyroid hormone and its receptors are significant regulators in the context of renal cell carcinoma.
  • Understanding these regulatory roles is crucial for potential therapeutic strategies in RCC.
  • Further research into the molecular mechanisms is warranted to fully elucidate the thyroid hormone's impact on RCC progression.