Related Experiment Video

Updated: Apr 29, 2026

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
07:32

Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library

Published on: September 30, 2019

7.4K

A Network Map of FGF-1/FGFR Signaling System

Rajesh Raju1, Shyam Mohan Palapetta2, Varot K Sandhya1

  • 1Institute of Bioinformatics, International Tech Park, Bangalore 560066, India.

Journal of Signal Transduction
|May 16, 2014
PubMed

Insights

Fibroblast growth factor-1 (FGF-1) signaling impacts cell growth and development. We created a resource detailing FGF-1/FGFR signaling pathways to aid research into its role in health and disease.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Biochemistry

Background:

  • Fibroblast growth factor-1 (FGF-1) is a key signaling molecule in the FGF superfamily, regulating critical cellular functions like growth, differentiation, and survival.
  • FGF-1 interacts with all four FGF receptors (FGFRs), influencing diverse physiological processes including development, angiogenesis, and wound healing.
  • Dysregulation of FGF-1 signaling is linked to tumorigenesis, invasion, and metastasis, highlighting its biomedical significance.

Purpose of the Study:

  • To address the lack of public resources for analyzing individual FGF-induced signaling pathways.
  • To develop a comprehensive resource detailing signaling reactions triggered by the FGF-1/FGFR system.
  • To provide downloadable pathway data and reaction maps in standard formats for research use.

Main Methods:

  • Curated and compiled data on signaling reactions initiated by FGF-1 binding to its cognate receptors.
  • Developed a pathway resource integrating information across various cell types and tissues.
  • Made pathway data and reaction maps available through the NetPath and NetSlim resources.

Main Results:

  • A novel resource detailing FGF-1/FGFR signaling pathways has been established.
  • The resource includes comprehensive data on signaling reactions triggered by FGF-1.
  • Pathway data and reaction maps are accessible for download in multiple standard formats.

Conclusions:

  • The developed resource facilitates focused analysis of FGF-1/FGFR signaling pathways.
  • This resource supports research into the role of FGF-1 in physiological processes and diseases.
  • Availability of curated pathway data enhances understanding of complex cell signaling networks.

More Related Videos

Oligomerization Dynamics of Cell Surface Receptors in Living Cells by Total Internal Reflection Fluorescence Microscopy Combined with Number and Brightness Analysis10:43

Oligomerization Dynamics of Cell Surface Receptors in Living Cells by Total Internal Reflection Fluorescence Microscopy Combined with Number and Brightness Analysis

Published on: November 6, 2019

6.7K
Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer08:20

Using Microarrays to Interrogate Microenvironmental Impact on Cellular Phenotypes in Cancer

Published on: May 21, 2019

5.1K

Related Concept Videos

Intracellular Signaling Affects Focal Adhesions01:17

Intracellular Signaling Affects Focal Adhesions

Integrins act both as extracellular input receivers and as intracellular processing activators. As their name suggests, integrins are entirely integrated into the membrane structure. Their hydrophobic membrane-spanning regions interact with the phospholipid bilayer's hydrophobic region. These membrane receptors provide extracellular attachment sites for effectors like hormones and growth factors. They activate intracellular response cascades when their effectors are bound and active.
Some...
2.8K
Transducer Mechanism: G Protein–Coupled Receptors01:30

Transducer Mechanism: G Protein–Coupled Receptors

G Protein–Coupled Receptors (GPCRs) are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to various stimuli. GPCRs regulate critical physiological pathways and are excellent drug targets for treating diseases such as diabetes, cancer, obesity, depression, or Alzheimer's. Nearly 35% of approved drugs implement their therapeutic effects by selectively interacting with specific GPCRs.
GPCRs are also called heptahelical,...
9.0K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K
Assembly of Signaling Complexes01:30

Assembly of Signaling Complexes

Multiprotein signaling complexes are formed in a dynamic process involving protein-protein interactions at the cytoplasmic domain of transmembrane receptors or enzymatic and non-enzymatic proteins associated with the receptor. These complexes ensure the activation and propagation of intracellular signals that regulate cell functions.
Interaction domains in cell signaling
Interaction domains recognize exposed features of their binding partners containing post-translationally modified sequences,...
4.7K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
4.7K
IP3/DAG Signaling Pathway01:11

IP3/DAG Signaling Pathway

Membrane lipids such as phosphatidylinositol (PI) are precursors for several membrane-bound and soluble second messengers. Specific kinases phosphorylate PI and produce phosphorylated inositol phospholipids. One such inositol phospholipids are the  phosphatidylinositol-4,5 bisphosphate [PI(4,5)P2], present in the inner half of the lipid bilayer. Upon ligand binding, GPCR stimulates Gq proteins to turn on phospholipase Cꞵ. Activated phospholipase Cꞵ cleaves PI(4,5)P2 and...
12.5K